Cas 131833-97-1 - Chiral Box Ligand For Asymmetric Catalysis

(R,R)-(+)-2,2'-Isopropylidenebis(4-tert-butyl-2-oxazoline) (CAS: 131833-97-1) is a premium-quality chiral bisoxazoline ligand belonging to the BOX ligand family. Thanks to its rigid chiral structure and bulky tert-butyl substituents, it offers excellent enantioselective control in various catalytic reactions. It is one of the most widely used ligands in asymmetric synthesis, particularly in academic research and pharmaceutical development. Key Applications 1. Asymmetric Catalysis This ligand forms highly efficient complexes with transition metals such as Cu, Fe, Ni, and Zn. These complexes are essential in asymmetric cyclopropanation, Diels–Alder reactions, Michael additions, 1,2- and 1,4-additions, and many other stereoselective transformations. 2. Pharmaceutical Development Its strong chiral induction ability makes it a preferred tool in the synthesis of chiral intermediates and APIs, especially those involving C–C or C–N bond formation with high enantiomeric purity. 3. Fine Chemicals & Specialty Materials The compound is used in producing high-value specialty chemicals where stereochemistry is essential for function and performance. We provide reliable global supply of chiral catalysts and ligands to support innovation in synthetic chemistry and pharmaceutical development.