Cas 131833-93-7 - High-Performance Chiral Bisoxazoline Ligand

(S,S)-(-)-2,2'-(Dimethylmethylene)bis(4-tert-butyl-2-oxazoline) (CAS: 131833-93-7) is a chiral BOX-type ligand designed for high-efficiency asymmetric catalysis. The compound features a symmetric bisoxazoline framework and sterically bulky tert-butyl groups, offering strong metal coordination and excellent enantioselectivity. It is widely applied in pharmaceutical synthesis, organometallic chemistry, and stereoselective transformations. Key Applications 1. Enantioselective Catalysis This ligand forms highly selective metal complexes with Cu, Zn, Fe, and other transition metals, enabling superior enantio-induction in reactions such as asymmetric oxidation, cycloaddition, epoxidation, and alkylation. 2. Drug Discovery & API Manufacturing It is frequently employed in the synthesis of chiral drug molecules and intermediates, where stereochemical precision is essential for biological activity and pharmaceutical performance. 3. Specialty Chemical Synthesis The ligand allows for the controlled formation of complex chiral building blocks used in fine chemicals, specialty materials, and functional molecular design. We provide high-quality chiral ligands to support cutting-edge research in asymmetric catalysis and complex molecule synthesis.