Sodium Ethoxide (Cas 141-52-6): Strong Alkoxide Base For Organic Synthesis

Sodium Ethoxide (CAS 141-52-6) is a strong alkoxide base and nucleophile widely used in organic synthesis. Typically supplied as a white to off-white solid or as a solution in ethanol, it is highly reactive toward moisture and must be handled under dry conditions. With the chemical formula C2H5NaO, sodium ethoxide plays a critical role in base-catalyzed transformations and condensation reactions. Applications Organic Synthesis: Sodium ethoxide is commonly employed in elimination (E2) reactions, transesterification, Claisen condensations, and Michael additions. As a strong base, it efficiently generates enolates and promotes carbon–carbon bond formation, making it an essential reagent in pharmaceutical and fine chemical manufacturing. Pharmaceutical Intermediates: In API synthesis, sodium ethoxide is used to facilitate key steps such as ester formation, cyclization, and alkylation reactions. Its predictable reactivity and compatibility with ethanol-based systems make it suitable for both laboratory and industrial processes. Agrochemicals and Specialty Chemicals: It serves as a catalyst or reagent in the preparation of herbicides, pesticides, and various specialty intermediates where controlled basic conditions are required. Biodiesel Production: Industrially, sodium ethoxide is applied as a transesterification catalyst in biodiesel manufacturing, improving reaction efficiency and product yield. UCHEM can supply Sodium Ethoxide (CAS 141-52-6) with consistent quality, suitable for laboratory research, pilot-scale production, and industrial applications. Stable supply and scalable production capacity are available upon request.