Cas 131833-93-7 - Chiral Ligand For Asymmetric Catalysis

(S,S)-(-)-2,2'-(Dimethylmethylene)bis(4-tert-butyl-2-oxazoline) CAS:131833-93-7 is a chiral bis(oxazoline) ligand widely used in asymmetric catalysis and enantioselective synthesis. Due to its rigid structure and well-defined stereochemistry, this compound plays an important role in the development of catalytic systems for producing optically active molecules. Chemical Characteristics This compound belongs to the bis(oxazoline) (BOX) ligand family. It contains two oxazoline rings connected through a dimethylmethylene bridge and substituted with tert-butyl groups, which provide steric control during catalytic reactions. The (S,S) configuration ensures a defined chiral environment, enabling high enantioselectivity in many transformations. (S,S)-(-)-2,2'-(Dimethylmethylene)bis(4-tert-butyl-2-oxazoline) typically appears as a white to off-white solid and is soluble in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. Applications in Scientific Research Asymmetric Catalysis This compound is widely used as a chiral ligand in metal-catalyzed reactions, particularly with copper, nickel, or zinc complexes. These catalytic systems are frequently applied in asymmetric cyclopropanation, Diels–Alder reactions, and other enantioselective transformations. Pharmaceutical Synthesis The ligand plays an important role in the synthesis of chiral intermediates used in pharmaceutical research. Enantioselective catalysis is crucial for preparing biologically active compounds with high stereochemical purity. Organic and Materials Chemistry Researchers also use bis(oxazoline) ligands to develop new catalytic methodologies and study structure–activity relationships in coordination chemistry and organometallic catalysis. Supply Information UCHEM can provide (S,S)-(-)-2,2'-(Dimethylmethylene)bis(4-tert-butyl-2-oxazoline) CAS:131833-93-7 with reliable purity and stable supply. The product is suitable for research laboratories, pharmaceutical development, and catalytic studies. Technical documentation such as COA and MSDS can be supplied upon request.