3-Ethynylaniline (Cas 54060-30-9) - In Stock For Pharmaceutical & Materials Science R&D

Product Overview 3-Ethynylaniline (CAS: 54060-30-9) is a high-value organic intermediate featuring both an amino group and a terminal alkyne functionality. This unique dual-reactive structure makes it an indispensable building block in pharmaceutical synthesis, click chemistry, and advanced polymer materials. CAS Number: 54060-30-9 EC Number: 258-944-6 Molecular Formula: C8H7N Molecular Weight: 117.15 g/mol Purity: =98% (GC) Appearance: Clear Liquid Key Applications 1. Pharmaceutical Intermediate 3-Ethynylaniline serves as a critical intermediate in the multi-step synthesis of erlotinib hydrochloride and icotinib – both are epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors used in non-small cell lung cancer treatment . It is also utilized in synthesizing quinazoline and nicotinic acid derivatives . 2. Click Chemistry & Organic Synthesis As a terminal alkyne, this compound is an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient construction of complex molecular architectures . This makes it valuable for drug discovery and bioconjugation applications. 3. Advanced Polymer Materials 3-Ethynylaniline is employed in the synthesis of high-performance benzoxazine monomers used in aerospace, aviation, and defense-grade composite resins . These materials offer exceptional thermal stability and mechanical properties. 4. Fluorescent Probes & Immunoassays Derivatives of 3-Ethynylaniline are used as important fluorescent labeling agents in immunoassays and bioanalytical detection systems. Contact us today for a quote or technical documentation.