Valinomycin (Cas 2001-95-8) - In Stock: Properties, Applications & Ordering

Product Profile Valinomycin CAS:2001-95-8 is a cyclic dodecadepsipeptide ionophore (C54H90N6O18, MW 1111.32) produced by Streptomyces fulvissimus. It exhibits exceptional selectivity for potassium ions (K?) over sodium (Na?) with a selectivity coefficient (K?/Na?) of approximately 104:1, facilitating K? diffusion across lipid bilayers at rates up to 105-fold above background. Mechanistic & Application Highlights 1. Ionophore in Membrane Transport Studies Valinomycin acts as a mobile carrier, encapsulating K? within its carbonyl-lined cavity. This property is widely exploited to collapse mitochondrial membrane potential (??m) in apoptosis and metabolic research. 2. Potassium-Selective Electrodes (ISEs) The gold-standard ionophore for polymeric membrane K?-selective electrodes. Valinomycin-based sensors achieve Nernstian response (slope 59.16 mV/decade at 25°C) with detection limits in the sub-micromolar range, critical for clinical diagnostics and environmental monitoring. 3. Chiral Stationary Phase Its asymmetric macrocyclic structure enables enantioselective recognition. Valinomycin has been successfully immobilized as an optically active stationary phase for GC, HPLC, and capillary electrophoresis, resolving racemates of amino acid derivatives and chiral drugs. 4. Bioactivity & Pharmacological Potential Induces caspase-dependent apoptosis in cancer cell lines (e.g., HeLa, MCF-7). Inhibits F0F1-ATPase, uncoupling oxidative phosphorylation. Suppresses neuronal differentiation via Ca²?-dependent pathways. Antagonizes endothelin-1-induced vasoconstriction in vitro. Exhibits insecticidal and plant growth-regulating activity, suggesting agrochemical applications. Quality & Supply ?In stock – ready for immediate dispatch ?Batch-specific COA provided with each order ?Packaging: 10 mg, 50 mg, 100 mg, 1 g, and bulk ?Custom synthesis available upon request For research and industrial use only.