5-Bromopyrimidine Cas 4595-59-9 - In-Stock Pyrimidine Building Block

5-Bromopyrimidine (CAS 4595-59-9) is a valuable heterocyclic intermediate widely used in pharmaceutical, agrochemical, and specialty chemical synthesis. As a brominated pyrimidine derivative, it serves as an important building block for the preparation of biologically active compounds and advanced functional molecules. Chemical Characteristics 5-Bromopyrimidine typically appears as a off-white crystal powder. The bromine substituent at the 5-position provides a highly reactive site for further functionalization through various carbon–carbon and carbon–heteroatom bond-forming reactions. Due to its electron-deficient pyrimidine ring, 5-bromopyrimidine readily participates in nucleophilic substitution and transition-metal-catalyzed cross-coupling reactions, making it a versatile intermediate in modern synthetic chemistry. Applications Pharmaceutical Synthesis 5-Bromopyrimidine is frequently used in the synthesis of active pharmaceutical ingredients (APIs) and drug discovery programs. Pyrimidine-containing structures are commonly found in kinase inhibitors, antiviral agents, and other therapeutic compounds. Cross-Coupling Reactions The bromine functionality enables efficient Suzuki, Sonogashira, Buchwald-Hartwig, and Stille coupling reactions, allowing the rapid construction of diverse pyrimidine derivatives. Agrochemical Development The compound is used in the preparation of crop protection products, including herbicide and fungicide intermediates. Research and Development Academic and industrial researchers utilize 5-bromopyrimidine as a key scaffold for the design of novel heterocyclic compounds and functional materials. Supply Advantage 5-Bromopyrimidine (CAS 4595-59-9) is available from stock, supporting immediate shipment and rapid project timelines. High purity, stable quality, and reliable supply make it suitable for both research and commercial production requirements.